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Because the BDNF gene plays a central role in regulating neuronal survival, synaptic plasticity, and the formation of new neural connections, individuals with this genotype typically maintain normal neurotrophic signaling capacity within brain networks responsible for learning, memory, and emotional regulation

For vitamin B12 to be absorbed from the gut, it must bind to a protein called intrinsic factor, which limits how much B12 the gut can take in at one time

doi: 10.1038/ncomms7670 42 MorissetteMRCookSABuranasombatiCRosenbergMARosenzweigA

As a result, this would further widen the disparities in care, especially in rural and underserved communities where treatment options may be limited